Chinases products named D.D.B able to decrease the level of liver enzymes
lets talk about it
It is a synthetic analogue of schisandrin C
Intestinal absorption a bout 70 % of
swallowed dose
Mainaly distributed in hepatic tissue
78% of DDB absorbed & bind to the blood protein
about 80% of the absorbed metabolized in healthy adult through first pass effect in liver
80% excreted via kidney un changed as glucouronic acid conjugate
half life 5-6 hours
D.D.B ameliorate HCV clinical symptoms
D.D.B improve hepatocyte inflammatory lesion such as mitochondrial swelling endoplasmic reticular sac dilation, polysomal dislocation& breakdown of endoplasmic reticulum membrane
D.D.B exerts its effect against liver damage as it improve the synthesis of intrinsic strustual proteins (free&bound ribosomes memebrane)of hepatocyte which closely related to structural &fuctional repair of damaged cells
D.D.B reduce the unscheduled DNA syunthesis(which induced by carcinogens)through increasing hepatic cytosol glutathione-5-transferaseµsomal UDPG-transferase activity ability to antagonize certain carcinogen induced DNA damage(as many carincogens should transformed into electrophile ultimate molecules through metabolic activation in liver microsomes before being covalently bouned to nucleophilic center of DNA(cause cell damage or gene mutation)
That is through several unpaired electrons of D.D.B molecules serve as nucleophilic centers competing with DNA for binding to these receptors
D.D.B inhibit carcinogens –induced UDS(excision repair) which is the most important repair mechanism of DNA damage by inhibition of carcinogen binding to DNA and modification of carcinogens metabolism (GST.UDPG-T&CYTO OXIDASE P-450)
D.D.B combined therapy for HCV INF (D.D.B +Amantadine)
D.D.B the ideal solution for steatoheapatis whatever the cause
D.D.B in combination with drugs inducing hepatitis for high risk patients intended for these drugs courses to overcome its hepatic overload .protection of heaptocyte &improving of detoxification capacity of heapto cyte
D.D.B IN combination with anti viral drugs (Amantadine HCL&rebavirin)
In viral hepatitis significantly improve patients cure rate &even seroconversion records
D.D.B is a timed-tested drug,high tolerable ,proven effective in Ameliorating clinical ,biochemical &histopathological manifestation for acute &chronic viral &non-viral hepatitis
DOSE &ADMINISTRATION
To achieve the max .results for elevated liver enzymes
Adminstraton &dosage(500 pilules\box 1.5 mg each)
Adult (over 12 years )0.75 mg/kg/day
Children (under 12 years ) 0.5 mg/kg/day
Divied into 3 equal doses (before meal)
Course of treatment
In acute heapatis 6- 12 months
In chronic hepatitis as long as the chronicity stands
There is no drug resistance have been reported
No side effects
Has no tetrogenic effects on pregnant rates & no paper reported that D.D.B has bad effects on pregnancy also D.D.B used in pregnant women in china
(N.B: Drug should be avoid in the st.trimenstrum)
lets talk about it
It is a synthetic analogue of schisandrin C
Intestinal absorption a bout 70 % of
swallowed dose
Mainaly distributed in hepatic tissue
78% of DDB absorbed & bind to the blood protein
about 80% of the absorbed metabolized in healthy adult through first pass effect in liver
80% excreted via kidney un changed as glucouronic acid conjugate
half life 5-6 hours
D.D.B ameliorate HCV clinical symptoms
D.D.B improve hepatocyte inflammatory lesion such as mitochondrial swelling endoplasmic reticular sac dilation, polysomal dislocation& breakdown of endoplasmic reticulum membrane
D.D.B exerts its effect against liver damage as it improve the synthesis of intrinsic strustual proteins (free&bound ribosomes memebrane)of hepatocyte which closely related to structural &fuctional repair of damaged cells
D.D.B reduce the unscheduled DNA syunthesis(which induced by carcinogens)through increasing hepatic cytosol glutathione-5-transferaseµsomal UDPG-transferase activity ability to antagonize certain carcinogen induced DNA damage(as many carincogens should transformed into electrophile ultimate molecules through metabolic activation in liver microsomes before being covalently bouned to nucleophilic center of DNA(cause cell damage or gene mutation)
That is through several unpaired electrons of D.D.B molecules serve as nucleophilic centers competing with DNA for binding to these receptors
D.D.B inhibit carcinogens –induced UDS(excision repair) which is the most important repair mechanism of DNA damage by inhibition of carcinogen binding to DNA and modification of carcinogens metabolism (GST.UDPG-T&CYTO OXIDASE P-450)
D.D.B combined therapy for HCV INF (D.D.B +Amantadine)
D.D.B the ideal solution for steatoheapatis whatever the cause
D.D.B in combination with drugs inducing hepatitis for high risk patients intended for these drugs courses to overcome its hepatic overload .protection of heaptocyte &improving of detoxification capacity of heapto cyte
D.D.B IN combination with anti viral drugs (Amantadine HCL&rebavirin)
In viral hepatitis significantly improve patients cure rate &even seroconversion records
D.D.B is a timed-tested drug,high tolerable ,proven effective in Ameliorating clinical ,biochemical &histopathological manifestation for acute &chronic viral &non-viral hepatitis
DOSE &ADMINISTRATION
To achieve the max .results for elevated liver enzymes
Adminstraton &dosage(500 pilules\box 1.5 mg each)
Adult (over 12 years )0.75 mg/kg/day
Children (under 12 years ) 0.5 mg/kg/day
Divied into 3 equal doses (before meal)
Course of treatment
In acute heapatis 6- 12 months
In chronic hepatitis as long as the chronicity stands
There is no drug resistance have been reported
No side effects
Has no tetrogenic effects on pregnant rates & no paper reported that D.D.B has bad effects on pregnancy also D.D.B used in pregnant women in china
(N.B: Drug should be avoid in the st.trimenstrum)
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